Interaction network and enrichment analysis of genes downregulated following Dexamethasone treatment
Canned Analysis
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General Information
AccessionDCA00034705
TitleInteraction network and enrichment analysis of genes downregulated following Dexamethasone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Dexamethasone treated cells and untreated control cells in the glucocorticoid (GC)-resistant lymphoblastic leukemia CEM-C7H2 T-ALL cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/HIST1H4C|LDHA|ACTG1|RPL4|PPP1CC|UBE2S|DDX21|PGAM1|SNRPD2|PSMA7|RPL8|RPL13A|RPLP0P6|NPM1|RPS3|PTTG1|SLC25A5|PPA1|RAN|SET|RPL9|YWHAG|HSP90AA1|DHX15|DYNLL1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2488
Cell Typeglucocorticoid (GC)-resistant lymphoblastic leukemia CEM-C7H2 T-ALL cell line
Drug NameDexamethasone
DrugBank IDDB01234
Organismhuman
PubChem CID5743
SMILES IDCC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM550942, GSM550943, GSM550944, GSM550945, GSM550946, GSM550947
Perturbed SamplesGSM550954, GSM550955, GSM550956, GSM550957, GSM550958, GSM550959
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE22152
Gene Expression Omnibus
Dexamethasone effect on glucocorticoid-resistant and -sensitive lymphoblastic leukemia cell lines
7
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