Interaction network and enrichment analysis of genes downregulated following Laccaic acid treatment
Canned Analysis
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General Information
AccessionDCA00034707
TitleInteraction network and enrichment analysis of genes downregulated following Laccaic acid treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Laccaic acid treated cells and untreated control cells in the MCF-7 breast cancer cells cell type.
Analysis URLhttp://genemania.org/#/search/human/S100A10|KRT8|MIR622|TGFB2|TIMP1|MYO1B|MIR4435-1HG|THBS1|ANXA2P2|ANXA2|SEPW1|NUTF2|KRT19|CLU|EEF2|MAP3K1|MIR21|ITGB6|CACNG4|PLK2|SLC38A2|LGALS1|NFKBIA|ANXA1|RPS16
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2490
Cell TypeMCF-7 breast cancer cells
Drug NameLaccaic acid
Organismhuman
PubChem CID5355255
SMILES IDCCC1=C(C2=C(C(=C1C(=O)C)O)C(=O)C3=C(C(=C(C=C3C2=O)O)C(=O)O)C(=O)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1115765, GSM1115767, GSM1115769
Perturbed SamplesGSM1115766, GSM1115768, GSM1115770
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45804
Gene Expression Omnibus
Laccaic acid effect on breast cancer cell line
12
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