Interaction network and enrichment analysis of genes downregulated following Vemurafenib treatment
Canned Analysis
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General Information
AccessionDCA00034723
TitleInteraction network and enrichment analysis of genes downregulated following Vemurafenib treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vemurafenib treated cells and untreated control cells in the BRAFV600E A375 human melanoma cells cell type.
Analysis URLhttp://genemania.org/#/search/human/HIST1H2BM|SLC43A3|HSPA8|HIST2H4A|HIST2H4B|DCBLD2|ACTN1|CAV1|LDLR|SERPINE2|DTL|KPNA2|PLK1|TUBB4B|SLC20A1|ALYREF|HIST1H3B|TUBG1|FST|PA2G4|ITGB3|CIRH1A|TGM2|HIST1H2BH|GPRC5A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2495
Cell TypeBRAFV600E A375 human melanoma cells
Drug NameVemurafenib
Organismhuman
PubChem CID42611257
SMILES IDCCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1052615, GSM1052616, GSM1052617
Perturbed SamplesGSM1052618, GSM1052619, GSM1052620
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42872
Gene Expression Omnibus
Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition
12
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