Interaction network and enrichment analysis of genes upregulated following Methylphenidate treatment
Canned Analysis
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General Information
AccessionDCA00034738
TitleInteraction network and enrichment analysis of genes upregulated following Methylphenidate treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Methylphenidate treated cells and untreated control cells in the brain cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ptgds|Hba-a1|Pmch|Rps19|Dnaja1|Scd2|Rps14|4932703K07Rik|9630010G10Rik|Akr1a1|Rps18|Ndufv1|Rpl34|Clk1|Hspa1b|Tmsb4x|Rps3a1|Ndufc1|Sepp1|Paip2|Rps17|Rps11|H2afz|App|Zc3h11a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2499
Cell Typebrain
Drug NameMethylphenidate
DrugBank IDDB00422
Organismmouse
PubChem CID4158
SMILES IDCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM831337, GSM831338, GSM831339
Perturbed SamplesGSM831340, GSM831341, GSM831342
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE33619
Gene Expression Omnibus
Methylphenidate effect on substantia nigra: dose response
7
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