Interaction network and enrichment analysis of genes upregulated following Vemurafenib treatment
Canned Analysis
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General Information
AccessionDCA00034764
TitleInteraction network and enrichment analysis of genes upregulated following Vemurafenib treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vemurafenib treated cells and untreated control cells in the Primary leukemic cells (purified from peripheral blood) - 48 Hours cell type.
Analysis URLhttp://genemania.org/#/search/human/OXTR|SLC16A9|NOD2|GPR133|PPP1R14A|LOC100506019|CDHR3|DPEP2|CHL1|HIST1H2AE|YPEL4|TMEM255A|LOC100505564|HIST1H2AM|LOC100506979|MIR663AHG|HIST1H2BC|HIST1H2BG|CXCL8|CHST15|HLA-DPB2|HIST1H3D|HIST2H2AA4|IL17D|PELI2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2508
Cell TypePrimary leukemic cells (purified from peripheral blood) - 48 Hours
Drug NameVemurafenib
DrugBank IDDB08881
Organismhuman
SMILES IDCCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c1c[nH]c2c1cc(cn2)c1ccc(cc1)Cl)F
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1557452, GSM1557458, GSM1557460, GSM1557464, GSM1557468, GSM1557472
Perturbed SamplesGSM1557453, GSM1557454, GSM1557459, GSM1557461, GSM1557465, GSM1557469, GSM1557473
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE63790
Gene Expression Omnibus
Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity
14
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