Interaction network and enrichment analysis of genes upregulated following Olanzapine treatment
Canned Analysis
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General Information
AccessionDCA00034770
TitleInteraction network and enrichment analysis of genes upregulated following Olanzapine treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Olanzapine treated cells and untreated control cells in the brain frontal cortex tissue cell type.
Analysis URLhttp://genemania.org/#/search/rat/Macf1|Ptgds|Vgf|Irgq|Ahnak|Spon1|LOC100912093|Fbxl5|Calr|Alcam|Plekhb1|Klf10|Sgk1|Pebp1|Kdm4c|Slc2a1|R3hdm1|LOC100912727|Kras|Bcl6|Wdr45b|Fosb|Bsg|Nefm|Myof
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2511
Cell Typebrain frontal cortex tissue
Drug NameOlanzapine
Organismrat
PubChem CID4585
SMILES IDCC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM48559, GSM48577, GSM48578, GSM48579
Perturbed SamplesGSM48580, GSM48581, GSM48582, GSM48583
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2547
Gene Expression Omnibus
Antipsychotic agent olanzapine effect on the brain frontal cortex
7
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