Interaction network and enrichment analysis of genes downregulated following Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00034775
TitleInteraction network and enrichment analysis of genes downregulated following Imatinib treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Imatinib treated cells and untreated control cells in the Chronic myelogenous leukemia CD34+ cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS26|MPO|RPL18AP3|RPS11|HBB|RPL29|RPS5|RPS15|RPL28|HBA2|RPLP2|RPL13|RPS19|EEF2|CD74|GLTSCR2|RPL8|RPL35|RPS4X|RPS21|RPL18|GAPDH|SLC25A5|CTSG|RPL13A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2521
Cell TypeChronic myelogenous leukemia CD34+ cells
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM23406, GSM23407, GSM23408, GSM23409, GSM23410, GSM23411
Perturbed SamplesGSM23412, GSM23414, GSM23415, GSM23416, GSM23418, GSM23420, GSM23421, GSM23423
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1418
Gene Expression Omnibus
Imatinib effects on chronic myelogenous leukemia CD34+ cells
7
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