Interaction network and enrichment analysis of genes upregulated following Fenretinide treatment
Canned Analysis
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General Information
AccessionDCA00034790
TitleInteraction network and enrichment analysis of genes upregulated following Fenretinide treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Fenretinide treated cells and untreated control cells in the CD34+ CML cells cell type.
Analysis URLhttp://genemania.org/#/search/human/HBD|UBC|CLC|RPS26|HBG2|RPSA|DCAF6|HSPA1A|GOLGA8H|SH3KBP1|PF4|HSPA8|DEFA1B|HBB|MLLT11|HSP90AA1|PPBP|NPM1|RPL36A|HMGN1|PSMD14|TMSB4XP8|FTL|IARS|HNRNPA1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2529
Cell TypeCD34+ CML cells
Drug NameFenretinide
DrugBank IDDB05076
Organismhuman
SMILES IDO=C(Nc1ccc(cc1)O)/C=C(/C=C/C=C(/C=C/C1=C(C)CCCC1(C)C)\C)\C
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM435978, GSM435979, GSM435980
Perturbed SamplesGSM435981, GSM435982, GSM435983, GSM435984, GSM435985
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17480
Gene Expression Omnibus
Transcriptome profiling of fenretinide-treated and untreated CD34+ cells from 4 CML patients
7
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