Interaction network and enrichment analysis of genes downregulated following Cadmium treatment
Canned Analysis
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General Information
AccessionDCA00034825
TitleInteraction network and enrichment analysis of genes downregulated following Cadmium treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Cadmium treated cells and untreated control cells in the TK6 cell type.
Analysis URLhttp://genemania.org/#/search/human/HIST1H3F|HIST1H4D|SNORD3D|HIST1H4C|RNU1-1|HIST1H4B|SNHG3|RNU2-2P|HIST1H4J|RPL13AP5|HIST1H3B|EIF5AL1|SNORD33|HIST1H4F|RNA18S5|RNU5D-1|RPL5|CD74|HSPA5|TCP1|ATP5B|RPSAP19|RN7SK|LGALS1|NBPF20
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatoralanstern
CREEDS IDdrug:2550
Cell TypeTK6
Drug NameCadmium
Organismhuman
PubChem CID23973
SMILES ID[Cd]
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM509197, GSM509198
Perturbed SamplesGSM509195, GSM509196
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20320
Gene Expression Omnibus
Lymphoblastoid cell response to low-dose cadmium exposure in vitro
14
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