Interaction network and enrichment analysis of genes downregulated following Plx4032 treatment
Canned Analysis
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General Information
AccessionDCA00034835
TitleInteraction network and enrichment analysis of genes downregulated following Plx4032 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Plx4032 treated cells and untreated control cells in the WM164 BRAF mutant Melanoma cells cell type.
Analysis URLhttp://genemania.org/#/search/human/ENO1|SERPINA3|IER3|MT2A|TM4SF1|HSPA8|CDK2AP1|SERPINE2|SPRY4|LDHA|HIST1H2BM|ANXA1|GAPDH|SLC43A3|PGK1|SLIRP|PKM|DHCR24|TUBB4B|SLC2A1|ACTN1|DHCR7|TUBG1|PPAP2B|SLC20A1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2556
Cell TypeWM164 BRAF mutant Melanoma cells
Drug NamePlx4032
DrugBank IDDB05238
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1322672, GSM1322673, GSM1322674
Perturbed SamplesGSM1322675, GSM1322676, GSM1322677
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE54711
Gene Expression Omnibus
Parent vs. Induced drug tolerant cells Microarray Analysis
7
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