Interaction network and enrichment analysis of genes upregulated following Plx4032 treatment
Canned Analysis
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General Information
AccessionDCA00034840
TitleInteraction network and enrichment analysis of genes upregulated following Plx4032 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Plx4032 treated cells and untreated control cells in the COLO829 human melanoma cell line-MITF Knockdown (BRAFV600E mutated) cell type.
Analysis URLhttp://genemania.org/#/search/human/DCT|NOV|ST6GALNAC2|TCN1|PLP1|KAT2B|TMEM47|ZEB2|MPZ|MATN2|P2RX7|PMP22|CRYAB|TGFBR2|MOXD1|ALCAM|TIMP2|SEMA3C|SNAI2|GPNMB|FAM129A|TUBA1A|ANK3|RAB38|ANGPTL7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2558
Cell TypeCOLO829 human melanoma cell line-MITF Knockdown (BRAFV600E mutated)
Drug NamePlx4032
DrugBank IDDB05238
Organismhuman
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1225717, GSM1225718
Perturbed SamplesGSM1225719, GSM1225720
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50649
Gene Expression Omnibus
COLO829 treatment with PLX4032 and/or MITF knockdown
14
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