Interaction network and enrichment analysis of genes upregulated following Doxycycline treatment
Canned Analysis
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General Information
AccessionDCA00034870
TitleInteraction network and enrichment analysis of genes upregulated following Doxycycline treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Doxycycline treated cells and untreated control cells in the C33KD2 cells cell type.
Analysis URLhttp://genemania.org/#/search/human/ZFHX4-AS1|FLJ37201|CELF2|HOXA1|MMP10|CCDC148|PGAM2|EMR4P|OTUD3|CDH18|ID4|MMAA|RGS22|RGS4|LACE1|C2orf76|LIPT1|ISL1|B4GALT6|SLC25A22|SOHLH2|CCDC79|NPAS4|EXOC6B|KIAA0825
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2573
Cell TypeC33KD2 cells
Drug NameDoxycycline
DrugBank IDDB00254
Organismhuman
PubChem CID5281011
SMILES IDCC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM287516, GSM288241, GSM288243
Perturbed SamplesGSM288248, GSM288249, GSM288260
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11422
Gene Expression Omnibus
Genes differentially expressed upon CHD8 knockdown
7
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