Interaction network and enrichment analysis of genes upregulated following Tamoxifen treatment
Canned Analysis
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General Information
AccessionDCA00034888
TitleInteraction network and enrichment analysis of genes upregulated following Tamoxifen treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Tamoxifen treated cells and untreated control cells in the pancreas cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Dmbt1|Gm10334|Pnliprp1|P4hb|Hsp90b1|Gm10653|Reg2|Rps2|Prss3|Cuzd1|Hspa5|Pdia6|Eef1a1|Hspa8|Txnip|Herpud1|Gc|Pdia2|Ahcy|Sec61a1|Ttr|Ctrb1|Vtn|Sord|Pnliprp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvcogliani
CREEDS IDdrug:2579
Cell Typepancreas
Drug NameTamoxifen
DrugBank IDDB00675
Organismmouse
PubChem CID2733526
SMILES IDCCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM845195, GSM845196, GSM845197, GSM845198
Perturbed SamplesGSM845203, GSM845204, GSM845205, GSM845206
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34232
Gene Expression Omnibus
Transcription factor MIST1-null and MIST1-induced pancreas
14
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