Interaction network and enrichment analysis of genes downregulated following Lapatinib treatment
Canned Analysis
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General Information
AccessionDCA00034891
TitleInteraction network and enrichment analysis of genes downregulated following Lapatinib treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Lapatinib treated cells and untreated control cells in the BT474 (lapatinib-sensitive) HER2+ breast cancer cells cell type.
Analysis URLhttp://genemania.org/#/search/human/COX1|COX2|DCAF6|SH3KBP1|RPL41|RPL19|H3F3AP4|ND2|EEF1A1P9|ACTG1|RPS18|PSMB3|RPLP0|RPL35|RPS20|TPT1|RPL30|FTH1P5|RPS3|RPS4X|RPS10|ACTB|RPL12|RPL9|TUBA1C
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2580
Cell TypeBT474 (lapatinib-sensitive) HER2+ breast cancer cells
Drug NameLapatinib
DrugBank IDDB01259
Organismhuman
PubChem CID208908
SMILES IDCS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM799168, GSM799169, GSM799170
Perturbed SamplesGSM799171, GSM799172, GSM799173
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16179
Gene Expression Omnibus
Lapatinib-resistant HER2-positive breast tumor cells
21
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