Interaction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00034925
TitleInteraction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells and untreated control cells in the cultured molar teeth from embryonic day 14 fetuses cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Lrrc6|Klra2|LOC100503923|Arhgap29|Ighv10-3|LOC434035|Hapln1|Sva|C78344|Cidec|Dio1|Abcb1a|Usp17la|Krtap6-3|Scn9a|Igkv6-23|D8Ertd107e|Slc32a1|Ret|Tal1|Acsm3|Ighv14-2|AA517023|Prss40|Epyc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdrug:2595
Cell Typecultured molar teeth from embryonic day 14 fetuses
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismmouse
PubChem CID15625
SMILES IDC1=C2C(=CC(=C1Cl)Cl)OC3=CC(=C(C=C3O2)Cl)Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM109312, GSM109590
Perturbed SamplesGSM109592, GSM109593
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4873
Gene Expression Omnibus
2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cultured embryonic teeth
7
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