Interaction network and enrichment analysis of genes downregulated following Etanercept treatment
Canned Analysis
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General Information
AccessionDCA00034927
TitleInteraction network and enrichment analysis of genes downregulated following Etanercept treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Etanercept treated cells and untreated control cells in the whole-blood leukocytes cell type.
Analysis URLhttp://genemania.org/#/search/human/HLA-A|FCN1|HLA-DRB5|ARHGDIB|OAZ1|CFD|FTL|TKT|H3F3A|HBA2|PSAP|S100A9|GZMB|FOLR3|EEF2|ARPC3|HBB|HLA-DRB1|CEBPB|TYROBP|HLA-DRA|NPC2|FGL2|LCP1|FCER1G
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2596
Cell Typewhole-blood leukocytes
Drug NameEtanercept
DrugBank IDDB00005
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM882389, GSM882391, GSM882393, GSM882395, GSM882397, GSM882399, GSM882401
Perturbed SamplesGSM882403, GSM882405, GSM882407, GSM882409, GSM882411, GSM882413, GSM882415, GSM882417
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36177
Gene Expression Omnibus
Genome-wide gene expression analysis of the whole blood leukocyte transcriptional response to endotoxin treatment
14
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