Interaction network and enrichment analysis of genes upregulated following Cytarabine treatment
Canned Analysis
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General Information
AccessionDCA00034934
TitleInteraction network and enrichment analysis of genes upregulated following Cytarabine treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Cytarabine treated cells and untreated control cells in the diffuse large B cell lymphoma SKI-DLCL cells cell type.
Analysis URLhttp://genemania.org/#/search/human/CYAT1|PRDX1|EEF1A1|MLLT11|EEF1B2|TUBA1C|RRM2|RPS10|RPS18|HLA-DRB5|RPL27|TMSB10|TUBA1B|CFL1|TCL1A|RPS26|TUBA4A|ISG15|ACTG1|ALDOA|TUBB4B|SNRPB|CD74|RPL23A|RPS15
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdrug:2599
Cell Typediffuse large B cell lymphoma SKI-DLCL cells
Drug NameCytarabine
DrugBank IDDB00987
Organismhuman
PubChem CID6253
SMILES IDC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM132917, GSM132918, GSM132920
Perturbed SamplesGSM132949, GSM132950, GSM132953
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5681
Gene Expression Omnibus
Aplidin and cytarabine effect on diffuse large B cell lymphoma cell line
14
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