Interaction network and enrichment analysis of genes downregulated following Methotrexate treatment
Canned Analysis
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General Information
| Accession | DCA00034937 |
| Title | Interaction network and enrichment analysis of genes downregulated following Methotrexate treatment |
| Description | The analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Methotrexate treated cells and untreated control cells in the PBMC (peripheral blood mononuclear cells) cell type. |
| Analysis URL | http://genemania.org/#/search/human/RPS26|GZMA|KLRB1|GNLY|IGJ|RPL12|CCL5|S100A4|CXCR4|RPL17|IL7R|GZMK|CD52|RPS20|PRF1|HLA-DRA|NKG7|TRBC1|GZMH|HLA-DQA2|GZMB|RPL23A|PLAC8|HLA-DRB4|SH3KBP1 |
| Upload Date | September 20, 2017 |
| Uploader | maayanlab |
Metadata
| Analysis Curator | MicrotaskManic |
| CREEDS ID | drug:2601 |
| Cell Type | PBMC (peripheral blood mononuclear cells) |
| Drug Name | Methotrexate |
| DrugBank ID | DB00563 |
| Organism | human |
| PubChem CID | 126941 |
| SMILES ID | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
Characteristic Direction parameters
| Gene Set | downregulated |
| Gene Set Size | 50 |
| Control Samples | GSM1025164, GSM1025165, GSM1025166, GSM1025167, GSM1025168, GSM1025169, GSM1025170, GSM1025171, GSM1025172, GSM1025173, GSM1025174, GSM1025175, GSM1025176, GSM1025177, GSM1025178 |
| Perturbed Samples | GSM1025179, GSM1025180, GSM1025181, GSM1025182, GSM1025183, GSM1025184, GSM1025185, GSM1025186, GSM1025187, GSM1025188, GSM1025189, GSM1025190, GSM1025191, GSM1025192 |
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