Interaction network and enrichment analysis of genes upregulated following Bexarotene treatment
Canned Analysis
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General Information
AccessionDCA00035084
TitleInteraction network and enrichment analysis of genes upregulated following Bexarotene treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Bexarotene treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/human/HLA-B|HLA-C|TIMP1|HLA-A|HIST1H2BK|B2M|HLA-G|H2BFS|ID1|ATP5F1|RPLP1|HLA-J|HIST1H1C|SAA2|HLA-DRB1|MORF4L1|RPN2|HEXB|CREG1|HLA-DRB5|NPC2|RPL13AP5|HIST2H2AA4|BTN3A2|LGALS3BP
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2681
Drug NameBexarotene
DrugBank IDDB00307
Organismhuman
PubChem CID82146
SMILES IDCC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM320837, GSM320841, GSM320845, GSM320849
Perturbed SamplesGSM320838, GSM320842, GSM320846, GSM320850
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE12791
Gene Expression Omnibus
Acquired paclitaxel-resistant MDA-MB-231 cancer cells response to bexarotene treatment
14
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