Interaction network and enrichment analysis of genes downregulated following Decitabine treatment
Canned Analysis
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General Information
AccessionDCA00035113
TitleInteraction network and enrichment analysis of genes downregulated following Decitabine treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Decitabine treated cells and untreated control cells in the melanoma cell type.
Analysis URLhttp://genemania.org/#/search/human/TUBA1B|TUBB|TUBA1C|ZWINT|RRM2|TUBB4B|PHB2|PFN1|RPS27A|VIM|NCL|NQO1|MCM3|CYCS|TGFBI|MCM6|SRSF2|YWHAZ|TUBB6|CCT3|TFRC|HSPD1|TUBB3|RAN|PTMA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2703
Cell Typemelanoma
Drug NameDecitabine
DrugBank IDDB01262
Organismhuman
PubChem CID451668
SMILES IDC1C(C(OC1N2C=NC(=NC2=O)N)CO)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM230901, GSM230903, GSM230905, GSM230907, GSM230909, GSM230911
Perturbed SamplesGSM230902, GSM230904, GSM230906, GSM230908, GSM230910, GSM230912
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9118
Gene Expression Omnibus
DNA methylation inhibitor effect on melanoma cell lines
7
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