Interaction network and enrichment analysis of genes downregulated following Dexamethasone treatment
Canned Analysis
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General Information
AccessionDCA00035131
TitleInteraction network and enrichment analysis of genes downregulated following Dexamethasone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Dexamethasone treated cells and untreated control cells in the Airway smooth muscle cells cell type.
Analysis URLhttp://genemania.org/#/search/human/MMP1|TNFRSF12A|HMOX1|TIMP1|TGFBI|SERPINE2|FST|LARP6|COL1A1|IER3|RPL26|LOC728392|LCE1D|SYCE1L|FHL2|CCL2|VASN|GDF15|VIM|DKK1|METRNL|ASNS|IER2|TUBA1B|CALM2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDdrug:3169
Cell TypeAirway smooth muscle cells
Drug NameDexamethasone
DrugBank IDDB01234
Organismhuman
PubChem CID5743
SMILES IDCC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM847200, GSM847201, GSM847202, GSM847203
Perturbed SamplesGSM847207, GSM847208, GSM847209
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE34313
Gene Expression Omnibus
Dexamethasone effect on cultured airway smooth muscle cells: time course
14
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