Interaction network and enrichment analysis of genes downregulated following Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00035177
TitleInteraction network and enrichment analysis of genes downregulated following Estradiol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Estradiol treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/human/PMP22|HIST2H2AA4|C6orf211|C3orf14|RPL8|RPL9|RPS10|RPLP0P6|BAMBI|RPS7|AMIGO2|MYL12B|ID1|RPL3|RPL13A|RPLP1|PSMB4|RPS18|LOC100093631|TRMT5|LINC00623|PLEKHF2|RPS15|DDIT4|CSDE1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2733
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM659805, GSM659806
Perturbed SamplesGSM659807, GSM659808, GSM659809
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26834
Gene Expression Omnibus
Estrogen or insulin-like growth factor I stimulated MCF-7 breast cancer cells: time course
14
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