Interaction network and enrichment analysis of genes downregulated following Estradiol treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035181
TitleInteraction network and enrichment analysis of genes downregulated following Estradiol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Estradiol treated cells and untreated control cells in the eralpha cell type.
Analysis URLhttp://genemania.org/#/search/human/RPL28|RPL4|RPLP1|RPSAP19|MT1P3|KRT81|RPL37|RPS11|RPS19|RPL37A|MIF-AS1|RPL38|HSPB1|RPL23AP74|LOC100130553|RPS2|RPL13A|RPS10|CYB5R3|RPL8|RPL27|RPS3|RPS17|CLU|RPL29P11
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2734
Cell Typeeralpha
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM19191, GSM19291
Perturbed SamplesGSM19292, GSM19293
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1153
Gene Expression Omnibus
Estradiol effect on osteosarcoma cells expressing estrogen receptor alpha or beta: time course
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.