Interaction network and enrichment analysis of genes upregulated following Folic acid treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035198
TitleInteraction network and enrichment analysis of genes upregulated following Folic acid treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Folic acid treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/human/FAM98B|FTH1|RPS4X|HLA-DRB5|CXCL8|TYMP|MLLT1|NPIPA1|UBC|NWD1|CCL2|ZFP36L1|SLFN13|GPNMB|UBA52|HLA-C|RPS7|CYP1B1|LIPA|ITM2B|ELMOD3|HEXB|ATP6V1B2|ZNF91|RPS23
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2748
Drug NameFolic acid
DrugBank IDDB00158
Organismhuman
PubChem CID6037
SMILES IDC1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM440157, GSM440158, GSM440159, GSM440160, GSM440161, GSM440162, GSM440163, GSM440164, GSM440165, GSM440166, GSM440167
Perturbed SamplesGSM440168, GSM440169, GSM440170, GSM440171, GSM440172, GSM440173, GSM440174, GSM440175, GSM440176, GSM440177
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17635
Gene Expression Omnibus
Folic acid effect on endothelial progenitor cells of type 1 diabetes patients
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.