Interaction network and enrichment analysis of genes downregulated following Medroxyprogesterone acetate treatment
Canned Analysis
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General Information
AccessionDCA00035221
TitleInteraction network and enrichment analysis of genes downregulated following Medroxyprogesterone acetate treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Medroxyprogesterone acetate treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/mouse/Prap1|Wfdc18|Olfm4|Ctla2b|Klk1b9|Fcgbp|Rps12|Ctla2a|Sprr1a|Gm4076|Hsd11b2|Cuzd1|Rpl17-ps9|Gsta4|Gpx1|Neat1|BC100530|Ltf|Prr13|Krt6b|Krt5|Vdac2|Rpl31-ps17|Cnn1|Gm6793
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2779
Drug NameMedroxyprogesterone acetate
DrugBank IDDB00603
Organismmouse
SMILES IDO=C1CC[C@]2(C(=C1)[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(OC(=O)C)C(=O)C)C)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM262682, GSM262683, GSM262684, GSM262685, GSM262686, GSM262687
Perturbed SamplesGSM262676, GSM262677, GSM262678, GSM262679, GSM262680, GSM262681
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10392
Gene Expression Omnibus
Medroxyprogesterone acetate effect on the pregnant cervix
7
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