Interaction network and enrichment analysis of genes downregulated in RARA Activation - AM580 (RARA Agonist)
Canned Analysis
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General Information
AccessionDCA00035259
TitleInteraction network and enrichment analysis of genes downregulated in RARA Activation - AM580 (RARA Agonist)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between RARA Activation - AM580 (RARA Agonist) cells and control cells in the Dendritic cells (DCs) cell type.
Analysis URLhttp://genemania.org/#/search/human/S100A4|CD1A|MMP12|TGFBI|CD1C|SLC27A3|F13A1|SYNGR2|DPYSL2|WFDC21P|LDHA|MRC1|C1orf162|FLNA|CLEC4A|RNASE6|GLIPR2|FGL2|LGALS1|CLEC10A|TXNIP|GGTA1P|GPX3|PEA15|ARRDC4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2385
Cell TypeDendritic cells (DCs)
Gene Symbol (human)RARA
Gene Symbol (mouse)Rara
Organismhuman
Perturbation TypeActivation - AM580 (RARA Agonist)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM132919, GSM132923, GSM132927
Perturbed SamplesGSM132922, GSM132925, GSM132929
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5679
Gene Expression Omnibus
PPAR-gamma activation and RAR-alpha inhibition effect on dendritic cells
14
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