Interaction network and enrichment analysis of genes upregulated following Carboplatin treatment
Canned Analysis
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General Information
AccessionDCA00035264
TitleInteraction network and enrichment analysis of genes upregulated following Carboplatin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Carboplatin treated cells and untreated control cells in the NSCLC adenocarcinoma cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/CALM2|RPS13|CFL1|EEF1A1|ACTG1|UBC|LDHA|RPLP0|ACTB|GAPDH|PPIA|RPS3|RPL39|RPS27L|AKR1C2|ALDH1A1|ALDH3A1|TPT1|YWHAQ|ACTN4|RPS24|TUBA1B|RPSA|ENO1|PRDX1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3060
Cell TypeNSCLC adenocarcinoma cell line
Drug NameCarboplatin
DrugBank IDDB00958
Organismhuman
PubChem CID38904
SMILES IDC1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt]
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM162889, GSM162890
Perturbed SamplesGSM162893, GSM162894
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7035
Gene Expression Omnibus
PPARgamma agonist and platinum-based drug effect on adenocarcinoma cell line
14
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