Interaction network and enrichment analysis of genes upregulated following Argyrin a treatment
Canned Analysis
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General Information
AccessionDCA00035386
TitleInteraction network and enrichment analysis of genes upregulated following Argyrin a treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Argyrin a treated cells and untreated control cells in the MCF7 breast adenocarcinoma cells - 24 Hours cell type.
Analysis URLhttp://genemania.org/#/search/human/ND2|SH3KBP1|COX1|DCAF6|ASS1|DDIT4|FTL|ATF4|EEF2|SLC25A6|S100P|COX2|SNHG5|GARS|RPS14P3|RPL36A|ZNF217|RPL13A|CCNG1|DSP|RPLP0P6|EIF3E|RPL29|RPS2|RAB6C
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3054
Cell TypeMCF7 breast adenocarcinoma cells - 24 Hours
Drug NameArgyrin a
Organismhuman
PubChem CID24978550
SMILES IDCCC1C2=NC(=CS2)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(=C)C(=O)N(CC(=O)N1)C)C)CC3=CNC4=C3C(=CC=C4)OC)CC5=CNC6=CC=CC=C65
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM212654, GSM212661, GSM297803
Perturbed SamplesGSM212659, GSM297802, GSM297806
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8565
Gene Expression Omnibus
Argyrin A effect on MCF7 breast cancer cells: time course
14
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