Interaction network and enrichment analysis of genes downregulated following Trichostatin a treatment
Canned Analysis
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General Information
AccessionDCA00035433
TitleInteraction network and enrichment analysis of genes downregulated following Trichostatin a treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Trichostatin a treated cells and untreated control cells in the F9 embryonal carcinoma cell line cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Slc32a1|Srrm2|Foxd3|AA407107|Fpr-rs4|Inhbb|C78513|Pkdcc|D2Wsu81e|Rrh|Clec4f|Mtrf1l|Adam28|AI594671|Maff|Acta1|Tcap|Lilrb4|Gba2|Hoxa11|Hipk1|D6Ertd47e|Rad54l|Ifna11|Pax9
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3085
Cell TypeF9 embryonal carcinoma cell line
Drug NameTrichostatin a
Organismmouse
PubChem CID444732
SMILES IDCC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM24053, GSM24054, GSM24055
Perturbed SamplesGSM24146, GSM24147, GSM24148
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1437
Gene Expression Omnibus
Embryonal carcinoma cell line response to retinoic acid or trichostatin A
14
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