Interaction network and enrichment analysis of genes downregulated following Cisplatin treatment
Canned Analysis
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General Information
AccessionDCA00035445
TitleInteraction network and enrichment analysis of genes downregulated following Cisplatin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Cisplatin treated cells and untreated control cells in the NCI-H460 human lung large cell carcinoma cell line - 2 Hours cell type.
Analysis URLhttp://genemania.org/#/search/human/RN7SL2|SNORA16A|DUSP1|SNORA38B|ACTG1|SNORA22|GDI1|PLK1|SNORA70B|TUBB|TIMP1|RN7SK|SNORA71D|RGS2|HSPA8|HSPA1A|TUBB4B|SNORA23|HIST1H2BM|ACTB|RNA18S5|SNORD116-20|CSNK2B|RMRP|SNORA70
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3095
Cell TypeNCI-H460 human lung large cell carcinoma cell line - 2 Hours
Drug NameCisplatin
DrugBank IDDB00515
Organismhuman
PubChem CID441203
SMILES IDN.N.Cl[Pt+2]Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1034057, GSM1034058, GSM1034059
Perturbed SamplesGSM1034075, GSM1034076, GSM1034077
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE42172
Gene Expression Omnibus
Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on gene expression in the NCI-H460 human lung large cell carcinoma ce...
14
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