Interaction network and enrichment analysis of genes upregulated following Cisplatin treatment
Canned Analysis
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General Information
AccessionDCA00035448
TitleInteraction network and enrichment analysis of genes upregulated following Cisplatin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Cisplatin treated cells and untreated control cells in the NCI-H460 human lung large cell carcinoma cell line - 24 Hours cell type.
Analysis URLhttp://genemania.org/#/search/human/MALAT1|RPL5|TM9SF3|ANXA1|LOC388022|PFN1P2|FN1|TOB1|TUG1|COL5A2|PDIA3P1|SLC38A2|CPS1|DNAJC10|TM9SF2|PAPSS2|PTPLAD1|ATP2A2|PPP1CC|PAPOLA|LAMC1|CTSL|ADAM9|AKR1B10|YWHAE
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3096
Cell TypeNCI-H460 human lung large cell carcinoma cell line - 24 Hours
Drug NameCisplatin
DrugBank IDDB00515
Organismhuman
PubChem CID441203
SMILES IDN.N.Cl[Pt+2]Cl
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1034084, GSM1034085, GSM1034086
Perturbed SamplesGSM1034102, GSM1034103, GSM1034104
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42172
Gene Expression Omnibus
Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on gene expression in the NCI-H460 human lung large cell carcinoma ce...
14
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