Interaction network and enrichment analysis of genes downregulated following Rosiglitazone treatment
Canned Analysis
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General Information
AccessionDCA00035457
TitleInteraction network and enrichment analysis of genes downregulated following Rosiglitazone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Rosiglitazone treated cells and untreated control cells in the hearts from obese diabetic C57BL/KsJ-db/db mice cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Fgg|Pck1|Apof|Alb|Iigp1|Mug1|Ces1c|Aadac|Cyp2j5|Rgn|Fabp1|Ambp|E030046B03Rik|Tcf21|Gc|Gm12185|Igtp|Mbl2|Ssty2|Cyp2c40|Slc2a12|Cma1|A930011G23Rik|Pon1|Kng1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorjustinenoel
CREEDS IDdrug:3100
Cell Typehearts from obese diabetic C57BL/KsJ-db/db mice
Drug NameRosiglitazone
Organismmouse
PubChem CID77999
SMILES IDCN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM904679, GSM904680, GSM904681, GSM904682, GSM904683
Perturbed SamplesGSM904684, GSM904685, GSM904686, GSM904687, GSM904688
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36875
Gene Expression Omnibus
Diabetic db/db heart response to rosiglitazone
7
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