Interaction network and enrichment analysis of genes upregulated following Ethanol treatment
Canned Analysis
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General Information
AccessionDCA00035466
TitleInteraction network and enrichment analysis of genes upregulated following Ethanol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Ethanol treated cells and untreated control cells in the lung alveolar type 2 cells (Sprague-Dawley males following 6 weeks of chronic ingestion of alcohol) cell type.
Analysis URLhttp://genemania.org/#/search/rat/LOC100363434|Sftpb|Ubc|Ubb|Nfkbia|Ly6i|Sftpa1|ND5|LOC683399|Jund|ND2|Tmsb4x|LOC100134871|Btg2|Atf3|CYTB|Rps29|ATP6|Scnn1a|Pigr|ND1|Cyp2b2|Tsc22d1|Sult1a1|Tpt1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3107
Cell Typelung alveolar type 2 cells (Sprague-Dawley males following 6 weeks of chronic ingestion of alcohol)
Drug NameEthanol
DrugBank IDDB00898
Organismrat
PubChem CID702
SMILES IDCCO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1332324, GSM1332325, GSM1332326, GSM1332327
Perturbed SamplesGSM1332328, GSM1332329, GSM1332330
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55243
Gene Expression Omnibus
Chronic ethanol ingestion effect on lung alveolar type 2 cell
7
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