Interaction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00035473
TitleInteraction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells and untreated control cells in the Pituitary gland (postnatal day70 male rats exposed in utero to dioxin at gestational day15) cell type.
Analysis URLhttp://genemania.org/#/search/rat/Ptgds|Rpl6|Tshb|Tpt1|Rpl29|Dusp1|Rps26|Rps6|Hba1|Rpl8|Prl|Hbb|Rps25|Lmo4|Sv2b|Rpl3|Rpl35|Scg3|Chgb|Atp5b|Tac1|Junb|Nmb|Egr1|Rps7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3112
Cell TypePituitary gland (postnatal day70 male rats exposed in utero to dioxin at gestational day15)
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismrat
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1168486, GSM1168487, GSM1168488
Perturbed SamplesGSM1168489, GSM1168490, GSM1168491
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48100
Gene Expression Omnibus
Dioxin exposure in utero effect on the hypothalamus at maturity
14
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