Interaction network and enrichment analysis of genes downregulated following Arachidonic acid treatment
Canned Analysis
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General Information
AccessionDCA00035499
TitleInteraction network and enrichment analysis of genes downregulated following Arachidonic acid treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Arachidonic acid treated cells and untreated control cells in the PC3 prostate cancer cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/ISG15|IFITM1|IFITM3|IFI27|MX1|IFITM2|IFIT1|HIST2H2AA4|FTH1|IFI6|RSAD2|RND3|HLA-C|FTH1P5|HLA-B|LGALS3BP|B2M|IRF7|HIST1H2AC|LOC100507328|UBE2L6|HIST1H2BD|IFIT3|TRIB3|MT1X
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDdrug:3171
Cell TypePC3 prostate cancer cell line
Drug NameArachidonic acid
DrugBank IDDB04557
Organismhuman
SMILES IDCCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCC(=O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM86079, GSM86081
Perturbed SamplesGSM86085, GSM86086
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3737
Gene Expression Omnibus
Arachidonic acid effect on prostate cancer cells
14
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