Interaction network and enrichment analysis of genes upregulated following Casiigly treatment
Canned Analysis
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General Information
AccessionDCA00035520
TitleInteraction network and enrichment analysis of genes upregulated following Casiigly treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Casiigly treated cells and untreated control cells in the HeLa cell line (treated with casiopeinas II-gly 40µM for 6 hours) cell type.
Analysis URLhttp://genemania.org/#/search/human/HSPA6|MT1X|HSPA1A|MT2A|UBC|HSPA1B|MT1HL1|DNAJB1|HMOX1|MT1E|LOC100505584|S100A4|RPL41|ATF4|RPL32|AKR1C3|FTH1|FTH1P5|LDHA|MT1H|GADD45A|RPS18|RPL36A|RPL39|RPL19
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3130
Cell TypeHeLa cell line (treated with casiopeinas II-gly 40µM for 6 hours)
Drug NameCasiigly
Organismhuman
PubChem CID144221079
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1025049, GSM1025050, GSM1025051
Perturbed SamplesGSM1025052, GSM1025053, GSM1025054
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41827
Gene Expression Omnibus
HeLa cell line response to chemotherapeutic Casiopeinas
7
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