Interaction network and enrichment analysis of genes upregulated following Doxorubicin treatment
Canned Analysis
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General Information
AccessionDCA00035586
TitleInteraction network and enrichment analysis of genes upregulated following Doxorubicin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Doxorubicin treated cells and untreated control cells in the KJD SV40 virus transformed epidermal keratinocyte cell type.
Analysis URLhttp://genemania.org/#/search/human/RNA28S5|SNHG1|MAGT1|SAT1|TIMP1|CST3|POLR2A|RNU6-15P|RNU6-1|NPC2|IFI27|IFITM3|IGFBP7|B2M|IFI6|HLA-B|NXF1|RPL13A|SERPINE2|CTSV|CDCA5|RNA18S5|GADD45B|ULBP2|IFITM2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3180
Cell TypeKJD SV40 virus transformed epidermal keratinocyte
Drug NameDoxorubicin
DrugBank IDDB00997
Organismhuman
PubChem CID31703
SMILES IDCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1400400, GSM1400401
Perturbed SamplesGSM1400412, GSM1400413
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE58074
Gene Expression Omnibus
Identifying the downstream effectors of E2F7 in squamous cell carcinoma (SCC) cells
14
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