Interaction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035601
TitleInteraction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells and untreated control cells in the Hematopoietic CD34+ cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS27A|GAPDH|RPL36A|RPL37|UBC|EEF1A1|RPL27|ENO1|RPL12|VIM|RPLP0P6|RPS10|EIF3E|RPL39|RLIM|TPT1|RPL24|RPS15A|RPL23A|HINT1|GLTSCR2|PABPC3|RPL10A|FTL|RPS24
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3189
Cell TypeHematopoietic CD34+ cells
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismhuman
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM595118, GSM595120, GSM595122, GSM595124
Perturbed SamplesGSM595119, GSM595121, GSM595123, GSM595125
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24193
Gene Expression Omnibus
Hematopoietic CD34+ cells exposed in vitro to dioxin
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.