Interaction network and enrichment analysis of genes downregulated following Mk-886 treatment
Canned Analysis
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General Information
AccessionDCA00035605
TitleInteraction network and enrichment analysis of genes downregulated following Mk-886 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Mk-886 treated cells and untreated control cells in the A549 cell line (lung cancer) cell type.
Analysis URLhttp://genemania.org/#/search/human/COX1|DCAF6|COX2|RPL39|FTH1P5|AKR1C3|EEF1A1P9|RPL27|TMSB4XP8|HSPE1|RPL34|RPS3|RPL21|DKK1|COX3|MYL12B|ID3|PRDX1|FTL|SNRPG|ERH|RPL26|NOP10|RPL30|RAN
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDdrug:3193
Cell TypeA549 cell line (lung cancer)
Drug NameMk-886
Organismhuman
PubChem CID3651377
SMILES IDCC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM75009, GSM75010, GSM75013, GSM75015
Perturbed SamplesGSM75011, GSM75012, GSM75014, GSM75016
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3202
Gene Expression Omnibus
MK886 treatment of H720 non-small cell lung cancer cell line
14
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