Interaction network and enrichment analysis of genes downregulated following Tibolone treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035621
TitleInteraction network and enrichment analysis of genes downregulated following Tibolone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Tibolone treated cells and untreated control cells in the Endometrium (postmenopausal) cell type.
Analysis URLhttp://genemania.org/#/search/human/MMP7|FOS|IER2|EGR1|VCAN|RPL24|RPS3|FAU|MIR21|LAPTM4B|RPL21|HLA-DRB4|RPS26|IGFBP3|HLA-DRB5|CYR61|RPL9|HLA-DRB1|RPL34|RPS10|FOSB|RPS14P3|ZFP36|PROM1|RPL11
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3204
Cell TypeEndometrium (postmenopausal)
Drug NameTibolone
Organismhuman
PubChem CID444008
SMILES IDCC1CC2=C(CCC(=O)C2)C3C1C4CCC(C4(CC3)C)(C#C)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM312508, GSM312549, GSM312551, GSM312552, GSM312553, GSM312554, GSM312555, GSM312557, GSM312559
Perturbed SamplesGSM312675, GSM312676, GSM312677, GSM312678, GSM312679, GSM312680, GSM312681, GSM312682, GSM312683
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12446
Gene Expression Omnibus
Tibolone hormone effect on postmenopausal endometrium
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.