Interaction network and enrichment analysis of genes upregulated following Adenosine triphosphate treatment
Canned Analysis
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General Information
AccessionDCA00035646
TitleInteraction network and enrichment analysis of genes upregulated following Adenosine triphosphate treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Adenosine triphosphate treated cells and untreated control cells in the AML FAB class M2 - acute myeloid leukemia lymphoblasts cell type.
Analysis URLhttp://genemania.org/#/search/human/IL1B|CXCL3|CXCL8|CCL3L3|SERPINB2|CXCL1|IL6|CCL4|PPBP|CYTIP|HIF1A|FTH1|CXCL6|CCR7|C15orf48|PTGS2|BCL2A1|DDIT4|MMP1|TXNIP|TNFAIP6|IER3|CCL20|IL7R|PFKFB3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3219
Cell TypeAML FAB class M2 - acute myeloid leukemia lymphoblasts
Drug NameAdenosine triphosphate
Organismhuman
PubChem CID5957
SMILES IDC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM766231, GSM766233, GSM766245
Perturbed SamplesGSM766232, GSM766234, GSM766246
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE30903
Gene Expression Omnibus
ATP effect on acute myeloid leukemia lymphoblasts
14
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