Interaction network and enrichment analysis of genes downregulated following Lmp-420 treatment
Canned Analysis
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General Information
AccessionDCA00035649
TitleInteraction network and enrichment analysis of genes downregulated following Lmp-420 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Lmp-420 treated cells and untreated control cells in the Primary chronic lymphocytic leukemia cell - 2 uM for 24 Hours cell type.
Analysis URLhttp://genemania.org/#/search/human/TXNIP|IGHA2|TMSB10|CCR7|DCAF6|RPL30|IGHV4-31|LAPTM5|HLA-DMB|RPL27|ND2|CXXC5|EVI2B|IGHM|RPS18|ID3|RPL32|S1PR1|CD52|RPS26|HMHA1|COX1|C4orf46|SH3KBP1|RPL35
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3222
Cell TypePrimary chronic lymphocytic leukemia cell - 2 uM for 24 Hours
Drug NameLmp-420
Organismhuman
PubChem CID497668
SMILES IDB(CCCCCN1C=NC2=C1N=C(N=C2Cl)N)(O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM506907, GSM506909, GSM506911, GSM506913, GSM506915, GSM506917, GSM506919, GSM506921, GSM506923, GSM506925, GSM506927, GSM506929, GSM506931
Perturbed SamplesGSM506908, GSM506910, GSM506912, GSM506914, GSM506916, GSM506918, GSM506920, GSM506922, GSM506924, GSM506926, GSM506928, GSM506930, GSM506932
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20211
Gene Expression Omnibus
Primary chronic lymphocytic leukemia cell response to purine nucleoside analog LMP-420
7
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