Interaction network and enrichment analysis of genes downregulated following Thapsigargin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035675
TitleInteraction network and enrichment analysis of genes downregulated following Thapsigargin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Thapsigargin treated cells and untreated control cells in the Immortalized B cells (from MZ twin pairs - African American ancestry) cell type.
Analysis URLhttp://genemania.org/#/search/human/HSPA8|IGJ|DNAJA1|RRM2|MS4A1|HSPE1|TUBA4A|TUBB4B|CKS2|HSPH1|DYNLL1|ZWINT|PLAC8|DHX15|SRSF2|TNFRSF17|IFI30|FEN1|MRPL36|HSP90AB1|CCT2|H3F3AP4|UHRF1|HSPA1A|IL2RB
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3236
Cell TypeImmortalized B cells (from MZ twin pairs - African American ancestry)
Drug NameThapsigargin
Organismhuman
PubChem CID446378
SMILES IDCCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM494452, GSM494454, GSM494456, GSM494458, GSM494460, GSM494462, GSM494464, GSM494466, GSM494468, GSM494470, GSM494472, GSM494474, GSM494476, GSM494478, GSM494480, GSM494482, GSM494484, GSM494486, GSM494488, GSM494490, GSM494492, GSM494494, GSM494496, GS
Perturbed SamplesGSM494453, GSM494455, GSM494457, GSM494459, GSM494461, GSM494463, GSM494465, GSM494467, GSM494469, GSM494471, GSM494473, GSM494475, GSM494477, GSM494479, GSM494481, GSM494483, GSM494485, GSM494487, GSM494489, GSM494491, GSM494493, GSM494495, GSM494497, GS
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19519
Gene Expression Omnibus
Endoplasmic reticulum stress effect on lymphoblastoid cells of monozygotic twins
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.