Interaction network and enrichment analysis of genes downregulated following 4-hydroxytamoxifen treatment
Canned Analysis
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General Information
AccessionDCA00035679
TitleInteraction network and enrichment analysis of genes downregulated following 4-hydroxytamoxifen treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 4-hydroxytamoxifen treated cells and untreated control cells in the MCF7 breast cancer cells - 100nM cell type.
Analysis URLhttp://genemania.org/#/search/human/TFF1|LCN2|TMSB4XP8|PABPC3|NQO1|RPL41|ACTB|KRT18|UBC|COX2|SERPINA3|CSTA|LXN|NFKBIA|RLIM|COX6C|MYL12B|FTH1P5|TPT1|EEF1A1P9|FBP1|EEF2|RPL30|DCAF6|RPS10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3239
Cell TypeMCF7 breast cancer cells - 100nM
Drug Name4-hydroxytamoxifen
Organismhuman
PubChem CID449459
SMILES IDCCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM645710, GSM645711, GSM645718, GSM645719
Perturbed SamplesGSM645712, GSM645713
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26298
Gene Expression Omnibus
Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells
21
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