Interaction network and enrichment analysis of genes upregulated following Sb 216763 treatment
Canned Analysis
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General Information
AccessionDCA00035752
TitleInteraction network and enrichment analysis of genes upregulated following Sb 216763 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Sb 216763 treated cells and untreated control cells in the RS4.11 leukemia cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/RPL13AP5|EEF2|PABPC1|LYZ|SNORD33|RPS27|HLA-B|HLA-A|RPS28|RPL17|CCNI|GAPDH|SLC25A6|RPL11|GNB2L1|LAPTM5|HLA-J|RPS3|HLA-C|ZNF160|FTL|RN7SL2|CD68|RPS2|RPS3A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3266
Cell TypeRS4.11 leukemia cell line
Drug NameSb 216763
Organismhuman
PubChem CID176158
SMILES IDCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM492838, GSM492846
Perturbed SamplesGSM492847, GSM492848, GSM492849
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19736
Gene Expression Omnibus
Glycogen synthase kinase 3 inhibitor effect on MLL leukemia cells
12
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