Interaction network and enrichment analysis of genes upregulated following Abiraterone treatment
Canned Analysis
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General Information
AccessionDCA00035810
TitleInteraction network and enrichment analysis of genes upregulated following Abiraterone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Abiraterone treated cells and untreated control cells in the No Data cell type.
Analysis URLhttp://genemania.org/#/search/human/NPC1|RN7SL2|MOB4|GRAMD1B|TIMP1|MIR202|RGS5|GSTA1|PAPSS2|RNA18S5|RHBDD2|CLU|CLDN11|PTP4A1|SPARC|S100A16|SCARB1|TMSB10|PRPS2|G6PD|APOD|HSD17B3|SNORD57|MIR503|CYP17A1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3300
Cell TypeNo Data
Drug NameAbiraterone
DrugBank IDDB05812
Organismhuman
SMILES IDO[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2c2cccnc2)C)C1)C
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1195853, GSM1195856, GSM1195857, GSM1195862, GSM1195865
Perturbed SamplesGSM1195851, GSM1195852, GSM1195854, GSM1195855, GSM1195858, GSM1195859, GSM1195860, GSM1195861, GSM1195863, GSM1195864, GSM1195866, GSM1195867
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE49244
Gene Expression Omnibus
Abiraterone acetate and di-n-butyl phthalate (DBP) response in a human fetal testis xenograft bioassay
7
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