Interaction network and enrichment analysis of genes downregulated following Methylphenidate treatment
Canned Analysis
FAIR Metrics
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General Information
AccessionDCA00035817
TitleInteraction network and enrichment analysis of genes downregulated following Methylphenidate treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Methylphenidate treated cells and untreated control cells in the Lymphoblastoid Cell Lines cell type.
Analysis URLhttp://genemania.org/#/search/human/CCL3L3|CCL4|IGJ|MT2A|PPIB|TNFRSF17|HMOX1|TXNDC5|PCNA|MT1X|RRM2|MT1H|ISCU|SPCS2P4|ISG20|RPL36AL|GARS|SRSF2|DAD1|IER3|PDIA6|ODC1|SF3B5|MT1HL1|ISG15
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3307
Cell TypeLymphoblastoid Cell Lines
Drug NameMethylphenidate
DrugBank IDDB00422
Organismhuman
PubChem CID4158
SMILES IDCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1277537, GSM1277538
Perturbed SamplesGSM1277539, GSM1277540
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52889
Gene Expression Omnibus
Effect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
7
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