Interaction network and enrichment analysis of genes upregulated following Metformin treatment
Canned Analysis
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General Information
AccessionDCA00035820
TitleInteraction network and enrichment analysis of genes upregulated following Metformin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Metformin treated cells and untreated control cells in the liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Apoa5|Ang|Hbb-bs|LOC100048884|Rdh7|Hba-a2|Itih4|Rnase4|Fgl1|Wfdc21|Igfbp2|Cyp2c50|Krt18|Mbl2|Ahsg|Cyp4a14|Itih3|Krt8|C9|Fgb|Eno1b|Serpina3m|Hsd3b7|Clu|Fga
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3308
Cell Typeliver
Drug NameMetformin
DrugBank IDDB00331
Organismmouse
PubChem CID4091
SMILES IDCN(C)C(=N)N=C(N)N
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM878116, GSM878117, GSM878118, GSM878119, GSM878120, GSM878121, GSM878122, GSM878123
Perturbed SamplesGSM878124, GSM878125, GSM878126, GSM878127
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35961
Gene Expression Omnibus
Liver response to a metformin supplemented high fat diet deficient in methionine and choline
7
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