Interaction network and enrichment analysis of genes downregulated following Concanavalin a treatment
Canned Analysis
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General Information
AccessionDCA00035869
TitleInteraction network and enrichment analysis of genes downregulated following Concanavalin a treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Concanavalin a treated cells and untreated control cells in the Liver (from Balb/C males) - 1 Hour cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Acaa1b|Hba-a2|Arrdc3|Hbb-bs|Fasn|Car3|Inmt|Scd1|Rnf125|Mup10|LOC100048884|Me1|Mettl7a2|Gm3601|Srebf1|Cyp4a12a|Hsd3b3|C730049O14Rik|Acsl5|Cyp2d9|Aldob|G0s2|Etnppl|Gstp1|LOC100503721
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3365
Cell TypeLiver (from Balb/C males) - 1 Hour
Drug NameConcanavalin a
Organismmouse
PubChem CID596316
SMILES IDCC1=C(C=C(C=C1)Cl)NC(=O)CSC2=NC3=CC=CC=C3N2
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM429426, GSM429428, GSM429430
Perturbed SamplesGSM429856, GSM429857, GSM429858
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17184
Gene Expression Omnibus
Concanavalin A-induced fulminant hepatitis model
21
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