Interaction network and enrichment analysis of genes upregulated following Pbde 47 treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00035910
TitleInteraction network and enrichment analysis of genes upregulated following Pbde 47 treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Pbde 47 treated cells and untreated control cells in the LIVERS (animals exposed to low doses from gestational day 15 to post-natal day 20) - 0.002mg/kg cell type.
Analysis URLhttp://genemania.org/#/search/rat/Pck1|Cth|Cyp2c22|Gsta2|G6pc|Slc25a47|Apoa2|Gsta5|Tat|Amacr|Cyp4a3|Gstm1|Cyp3a2|Fabp7|Ctsl|Hamp|Eci1|Dusp1|Crot|Cyp2c12|Plin2|Ftl1|Apoe|Insig2|Rpl4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3392
Cell TypeLIVERS (animals exposed to low doses from gestational day 15 to post-natal day 20) - 0.002mg/kg
Drug NamePbde 47
Organismrat
PubChem CID95170
SMILES IDC1=CC(=C(C=C1Br)Br)OC2=C(C=C(C=C2)Br)Br
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM496404, GSM496405, GSM496406, GSM496407, GSM496408, GSM496409
Perturbed SamplesGSM496410, GSM496411, GSM496412, GSM496413, GSM496414, GSM496415
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19868
Gene Expression Omnibus
Liver response to perinatal exposure to 2,2',4,4'-tetrabromodiphenyl ether: dose response
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.